Delay in starting clozapine and treatment guidelines

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Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation.

BACKGROUND Clozapine is the only antipsychotic drug licensed for treatment-resistant schizophrenia but its use is often delayed. Since previous studies, national guidelines on the use of clozapine and other antipsychotics have been disseminated to clinicians. AIMS To determine the theoretical delay to clozapine initiation and to quantify the prior use of antipsychotic polypharmacy and high-do...

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Clozapine in Treatment of Schizophrenia

The introduction of clozapine for the treatment of non responsive patients with schizophrenia has determined a real hope among patients, families and psychiatrists. This treatment is available that appears to be more effective than the standard or typical neuroleptics for many such treatment-resistant schizophrenic patients. A growing number of reports suggest that clozapine may also have a rol...

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Relation of blood counts during clozapine treatment to serum concentrations of clozapine and nor-clozapine.

OBJECTIVE To determine the relation between serum clozapine and nor-clozapine levels and blood cell counts during clozapine treatment. METHOD We undertook a prospective longitudinal study of 37 consecutive patients with a diagnosis of schizophrenia treated with clozapine. We obtained informed consent and then determined serum concentrations of clozapine and nor-clozapine weekly. Clozapine was...

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ژورنال

عنوان ژورنال: British Journal of Psychiatry

سال: 2013

ISSN: 0007-1250,1472-1465

DOI: 10.1192/bjp.202.2.154b